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A new chemotherapeutic for liver cancer

Uttrocide 1

What is liver cancer?

The liver is the football-sized organ in the upper right area of the belly. Symptoms are uncommon in the early stages of liver cancer. Later, symptoms may include weight loss, belly pain, vomiting, and yellowed skin. Treatments vary but may include removal of part of the liver, transplant, chemotherapy, and in some cases radiation.

What causes liver cancer?

Primary liver cancer (hepatocellular carcinoma) tends to occur in livers damaged by birth defects, alcohol abuse, or chronic infection with diseases such as hepatitis B and C, hemochromatosis (a hereditary disease associated with too much iron in the liver), and cirrhosis.

Who is most likely to get liver cancer?

In the United States, the average age at onset of liver cancer is 63 years. Men are more likely to develop liver cancer than women, by a ratio of 2 to 1. In the United States, liver cancer rates are highest in Asian Americans and Pacific Islanders. White Americans have the lowest risk for liver cancer. Chronic infection with Hepatitis B virus (HBV) or Hepatitis C virus (HCV) is the most common liver cancer risk factor. These infections lead to cirrhosis of the liver (see below).

liver cancer on rise 400

What are the symptoms of liver cancer?

Symptoms are uncommon in the early stages of liver cancer. Later, symptoms may include weight loss, belly pain, vomiting, and yellowed skin.

Current standard of care

RADIATION

High-energy x-rays or other 
particles destroy cancer cells

DRUG TREATMENT

Tryosine kinase inhibitor
antineoplastic agent, Nexavarâ„¢

SURGICAL

Hepatectomy or liver transplantation

CHEMOTHERAPY

Radiofrequency ablation (RFA) and
microwave therapy

THERMAL

Percutaneous ethanol injection

o LIVER CANCEL

Uttroside-B chemotherapeutic

P Uttroside-B appears to affect phosphorylated JNK (pro survival signaling) and capcase activity (apoptosis inliver cancer)

  • A natural compound
  • Fractionated Saponin derived from S. nigrum
  • Small molecule
  • Steroid Glycosided

Uttroside-B increases the cytotoxicity of a variety of liver cancer cell types

  • Up to 10x more potent than Sorafenib in pre clinical studies

Cytotoxicity specific to cancerous liver cells

Provisional patent filed

IND Ready Q1 2018

Sorafenib Tosylate (Nexavarâ„¢) is the only FDA- approved marketed drug for the treatment of liver cancer. 2016 sales exceeded $ 1 B.

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