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Chemotherapeutic for Liver Cancer
10th Most Common Cancer
Estimated 39,230 adults in the United States will be diagnosed
every year Short 1-year survival rate
More than 700,000 people worldwide are diagnosed each year
Surgical Hepatectomy or Liver Transplantation
Radiofrequency ablation (RFA) and microwave therapy
Percutaneous ethanol injection
Alcohol is injected directly into the liver tumor
High-energy x-rays or other particles destroy cancer cells
tryosine kinase inhibitor antineoplastic agent, Nexavar™
Sorafenib Tosylate (Nexavar™) is the only FDA approved drug for the treatment of liver cancer. 2016 Sales exceeded $1 billion.
Uttroside-B increases the cytotoxicity of a variety of liver cancer cell types and has been shown in pre-clinical studies to be 10x
more potent than Sorafenib.
Its cytotoxicity specific to cancerous liver cells.
P Uttroside-B appears to affect phosphorylated JNK (pro survival signaling) and capcase activity (apoptosis in liver cancer)
A natural compound
-Fractionated Saponin derived from S. nigrum